Enweela mmasị na-arịwanye elu na uru ahụike na ogologo ndụ nke NMN (Nicotinamide Mononucleotide) na-agbakwunye na afọ ndị na-adịbeghị anya. Dị ka onye ebe sayensị na ọdịmma na-agafe masị nke ukwuu, agara m njem nlegharị anya iji nyochaa isiokwu a n'ihu. Achọrọ m ịkọwapụta usoro dị n'azụ ntinye NMN na ihe ọ pụtara maka ahụike mmadụ na ogologo ndụ site na nyocha na nyocha nke ọma.
Ịchọgharị Sayensị n'azụ NMN
Usoro sayensị nke na-akwado ntinye NMN (Nicotinamide Mononucleotide) dị mkpa maka ịghọta nrụpụta ya. NMN bụ precursor ozugbo na nicotinamide adenine dinucleotide (NAD +), coenzyme dị mkpa na-etinye aka na metabolism ike, nrụzi DNA, na usoro okwu mkpụrụ ndụ ihe nketa, ihe niile dị mkpa maka ahụike. Mgbakwunye NMN nwere ike ịnye uru ọgwụgwọ nwere ike na ịka nká na ọrịa ndị metụtara afọ site n'ịkwalite ọkwa NAD +. Nke a nwere nkwa maka ịkwalite ọrụ ekwentị, ịkwalite ogologo ndụ, na ibelata ọdịda metụtara afọ."
Ikpughe njikọ dị n'etiti NMN na Ụzọ Ogologo Ndụ
Ụzọ sirtuin bụ otu n'ime ụzọ ndị bụ isi site na ya Β-Nicotinamide Mononucleotidenmn na-emetụta ogologo ndụ. Sirtuins bụ ezinụlọ nke NAD +-dabere na protein deacetylases nke na-ahazi usoro usoro ndu dị iche iche nke dị mkpa maka ịgbanwe ndụ ndụ ma nyere aka ịnọgide na-enwe homeostasis cellular. NMN Nicotinamide Mononucleotide ntụ ntụ, site n'inyere ọkwa NAD + aka, kwalite mmegharị sirtuin, bụ nke a na-agụkarị maka ike ya ịmegharị usoro ntozu oke ma gbasaa ogologo ndụ. Ụzọ na-ekwe nkwa maka nyocha ntinye aka nke ezubere iji kwalite ịka nká na ogologo ndụ na-eme ka ọ pụta ìhè site na ịgbalite sirtuins site na mgbakwunye NMN.
Ntụle Mmetụta dị na Ahụike Metabolic
Ịgbakwunye NMN (Nicotinamide Mononucleotide) adọtala ọtụtụ nlebara anya n'ihi Β-Nicotinamide Mononucleotidenmn enwere ike inwe mmetụta na ahụike metabolic na mgbakwunye na ọrụ a ma ama na ịgbatị ndụ. Nnyocha na-egosi na NMN nwere ike ịbawanye mmetụta insulin ma melite ọrụ mitochondrial, nke bụ akụkụ dị mkpa nke mmepụta ike cellular. Nsonaazụ ndị a na-egosi na NMN nwere ike inye aka maka ndị nwere ọnọdụ metabolic gụnyere ụdị ọrịa shuga 2 na oke ibu.
Site n'ịkwalite ụzọ metabolic site na mmetụta ya na ọrụ mitochondrial na mmetụta insulin, NMN na-ekwe nkwa ọ bụghị naanị ịgbatị ndụ kamakwa n'ịkwalite ahụike na ịdị ike nke metabolic n'ozuzu ya. Nnyocha na-aga n'ihu n'ime usoro NMN na ike ọgwụgwọ na ahụike metabolic nwere ike ikpughe usoro ọhụụ maka ijikwa na igbochi ọrịa metabolic."
Na-agwa Senescence Cellular na mmebi DNA
Inweta mgbakwunye NMN (Nicotinamide Mononucleotide) yiri ka ọ bụ ụzọ dị mma isi lụso senescence cellular metụtara ịka nká na mmebi DNA. Ka mkpụrụ ndụ na-akawanye nká, ha na-anakọta mgbanwe DNA ma na-enweta ire ure bara uru, nke na-agbakwunye na ọrịa ndị toro eto. Site n'ịkwado nrụpụta cellular na ịkwalite usoro nrụzi DNA, NMN na-egosipụta ikike ibelata mmetụta ndị a. Site n'ịkwalite ikike cell ka mma, mgbakwunye NMN nwere ike ịgbakwunye n'ịgbasa ndụ ndụ yana ịrụ ọrụ na ịdị mma n'ozuzu ya na ndị tozuru etozu. "
Inyocha ihe akaebe sitere na ọmụmụ mmadụ
Ọ bụ ezie na ọmụmụ ihe izizi gosipụtara nsonaazụ na-ekwe nkwa, ọ dị oke mkpa inyocha ihe akaebe sitere na nnwale mmadụ iji ghọta nke ọma ihe mgbakwunye NMN pụtara. Emeela ọtụtụ ule ụlọ ọgwụ iji nyochaa nchekwa na ịdị irè nke NMN n'ime mmadụ, na-ekpughe nchọpụta mmalite nke na-egosi nsonaazụ dị mma na paramita metabolic, ịrụ ọrụ anụ ahụ, na ịdị mma n'ozuzu ya. Nghọta ndị a na-enye ntọala bara uru maka ịgakwuru n'ihu nyocha uru na njedebe NMN nwere na ahụike mmadụ."
Ịghọta mkpa nke usoro onunu ogwu na nchịkwa
Ịdị irè nke NMN dị ka ihe mgbakwunye nri na-adabere na usoro ọgwụgwọ na omume nchịkwa kwesịrị ekwesị. Usoro ọgwụgwọ kachasị mma nwere ike ịdị iche dabere na ihe onye ọ bụla dị ka afọ, ọnọdụ ahụike, na profaịlụ metabolic. Ya mere, ọ dị oke mkpa maka ndị mmadụ n'otu n'otu na-atụgharị uche na mgbakwunye NMN ịchọ nduzi n'aka ndị ọkachamara ahụike. Ijikọ ọnụ na-echepụta ụkpụrụ ahaziri iche na-ahụ na nke ahụ nnukwu nmn nicotinamide mononucleotide ntụ ntụ a na-eji ya eme ihe n'ụzọ dị irè iji gboo mkpa na ihe mgbaru ọsọ ahụike kpọmkwem, na-eme ka uru ya dị elu ma na-ahụ maka nchekwa na ịdị irè."
Ịgagharị n'ọdịdị ala nke NMN Mmeju
Ọ na-achọ nnukwu echiche iji gaa na ngwaahịa NMN n'ahịa mgbakwunye nri na-eto eto. Ido mma na ịdị ọcha ụzọ dị oke mkpa. Iji mee nke a, họrọ ngwaahịa ndị a pụrụ ịdabere na ya na-agbaso ụkpụrụ nrụpụta siri ike wee gaa nyocha dị ukwuu iji lelee adịghị ọcha na ike. Uru ndị ọzọ nwere ike ibilite site n'ịchọpụta ihe ndị na-emekọrịta ihe, dị ka quercetin na resveratrol, nke nwere ike imeziwanye irè nke NMN. Site na ime mkpebi mara nke ọma gbadoro ụkwụ n'ụkpụrụ ndị a, ndị na-azụ ahịa nwere ike bulite uru ahụike nwere ike ịnweta mgbakwunye NMN."
Ịnabata usoro zuru oke maka Ogologo ndụ
Ọ bụ ezie na mgbakwunye NMN na-egosi nkwa n'ịkwalite ahụike na ogologo ndụ, ụzọ zuru oke nke gụnyere ụdị ndụ dị iche iche dị oke mkpa. Ịgbakwunye mmega ahụ mgbe niile, nri ziri ezi, njikwa nrụgide dị irè, na ụra zuru oke na-akwado ahụike cellular na ogologo ndụ. Site n'itinye mgbakwunye NMN n'ime usoro ahụike zuru oke nke ahaziri maka mkpa onye ọ bụla, ndị mmadụ n'otu n'otu nwere ike ịkwalite ogologo ahụike ha wee kwalite ogo ndụ ha. Usoro a nwere ọtụtụ ihe ọ bụghị naanị na-eleba anya ebumnuche ahụike ozugbo kamakwa ọ na-akwalite ọdịmma ogologo oge, na-akwalite ndụ dị egwu na nke na-eju afọ."
mmechi
Na mkpokọta, Β-Nicotinamide Mononucleotidenmn Mgbakwunye na-ekwu maka ihe na-akpali akpali na ngalaba nyocha ogologo ndụ, na-enye ahụmahụ na-adọrọ mmasị n'ime ihe ndị bụ isi na-eto eto na ọrịa ndị metụtara afọ. Site na mmetụta ya dị mgbagwoju anya na ikike cell, mgbari nri, na ntụkwasị obi DNA, NMN na-ejide nkwa dị ka ngwaọrụ maka ịkwalite ogologo ahụike yana ịkwalite mkpa ọ dị n'ime ọha mmadụ. Agbanyeghị, nyocha agbakwunyere dị mkpa iji dokwuo anya mmetụta ya na-adịte aka yana guzobe ụkpụrụ ntụzịaka ojiji. Anyị nwere ike ịmalite njem gaa n'ọdịniihu nke ahụ dị mma na nke na-eju afọ site n'ịnabata usoro mkpali maka ịdịmma nke jikọtara mgbakwunye NMN na mgbanwe ndụ ka anyị na-agagharị na mgbagwoju anya nke ịka nká.
Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ nwee mmasị na ngwaahịa anyị, biko kpọtụrụ anyị: kiyo@xarbkj.com.
References
1.Imai S, Guarente L. NAD+ na sirtuins na ịka nká na ọrịa. Trends Cell Biol. 2014;24 (8): 464-471 .
2.Mills KF, Yoshida S, Stein LR, et al. Nlekọta ogologo oge nke nicotinamide mononucleotide na-ebelata mbelata physiological metụtara afọ na ụmụ oke. Cell Metab. 2016;24 (6): 795-806 .
3.Zhang H, Ryu D, Wu Y, et al. Mmeju nke NAD + na-eme ka ọrụ mitochondrial na stem cell na-eme ka ọ dịkwuo ogologo ndụ na ụmụ oke. Sayensị. 2016;352(6292):1436-1443 .
4.Gomes AP, Price NL, Ling AJ, et al. Mbelata NAD + na-ebute steeti pseudohypoxic na-akpaghasị nkwukọrịta nuklia-mitochondrial n'oge ịka nká. Cell. 2013; 155 (7): 1624-1638 .
5.Yoshino J, Mills KF, Yoon MJ, et al. Nicotinamide mononucleotide, onye isi NAD + etiti, na-agwọ ọrịa pathophysiology nke nri na ọrịa shuga na-ebute afọ na ụmụ oke. Cell Metab. 2011;14 (4): 528-536 .
6.Canto C, Houtkooper RH, Pirinen E, et al. NAD (+) precursor nicotinamide riboside na-akwalite metabolism oxidative ma na-echebe megide oke ibu na-ebute nri nwere abụba. Cell Metab. 2012;15 (6): 838-847 .
